MBA\u2122 Fluid Circulation & Material Retention Properties<\/h3>\n\n\n\n

Spherical-shaped MBs have unique properties of fluid flow as compared to typical micro-physiologic system (MPS) devices. Typical MPS devices culture cells in direct contact with fluid flow which imparts shear stress. For certain cell types including endothelial cells, shear stress is physiologically important to recapitulate in vivo<\/em> function. However, most cells and tissues in the body are not subjected to shear stress at the levels imparted in typical microfluidic MPS devices. Cells and tissues cultured in MBA\u2122 mounted in a microfluidic system experience low shear stress but with well developed fluid flows within the MB important for reagent and nutrient delivery. Nidus explicitly leverages these properties to obtain superior performance in multiple application areas.<\/p>\n\n\n\n